Israeli examine factors to modest 4-dose vaccine safety towards Omicron
4-dose efficacy of mRNA vaccines towards symptomatic Omicron COVID-19 an infection is modest, in keeping with a analysis letter yesterday within the New England Journal of Drugs that described a small examine in Israel.
Of 1,050 eligible Israeli healthcare employees, 154 acquired a fourth dose of Pfizer and 120 acquired a fourth dose of Moderna. The researchers chosen two age-matched controls from the remaining eligible individuals for every particular person vaccinated.
The fourth dose produced a strong immune response and triggered no regarding hostile occasions. General, 25.0% of the volunteers within the management group have been contaminated with Omicron, in contrast with 18.3% within the Pfizer group and 20.7% within the Moderna group.
The researchers reported vaccine efficacy of 30% for Pfizer and 11% for Moderna for any SAR-CoV-2 an infection, however neither vaccine achieved statistical significance for this measure. Vaccine safety towards symptomatic COVID-19 was 43% for Pfizer and 31% for Moderna. Omicron accounted for 100% of circulating SARS-CoV-2 in Israel on the time of the examine.
The authors be aware, “Our cohort was too small to permit for correct dedication of vaccine efficacy. Nonetheless, throughout the large confidence intervals of our estimates, vaccine efficacy towards symptomatic illness was 65% at most.”
They conclude, “A fourth vaccination of wholesome younger well being care employees could have solely marginal advantages. Older and susceptible populations weren’t assessed.” Additionally, they didn’t assess a fourth dose towards extreme COVID-19.
Mar 16 N Engl J Med study
Mothers unfold COVID-19 to newborns lower than 2% of time, knowledge present
SARS-CoV-2 is transmitted from mom to child earlier than, throughout, and after childbirth about 1.8% of the time, and vaginal births and breastfeeding don’t elevate the chance, finds a meta-analysis as we speak in BMJ.
A global analysis workforce led by the College of Birmingham’s World Well being Group Collaborating Centre for International Ladies’s Well being analyzed knowledge from 140 research from across the globe that included 14,271 infants born to moms with COVID-19. They discovered an total COVID-19 an infection fee of 1.8% (95% confidence interval, 1.2% to 2.5%), as decided by polymerase chain response (PCR) testing.
Of the 800 COVID-positive fetuses or infants with final result knowledge, 20 have been stillbirths, 23 died in the course of the first 28 days of life, and eight have been early being pregnant losses; 749 infants (93.6%) have been alive on the finish of follow-up.
The authors conclude, “Extreme maternal covid-19 could also be related to SARS-CoV-2 positivity in infants, however not vaginal supply, breastfeeding, or mother-baby contact after beginning.”
Senior creator Shakila Thangaratinam, MD, PhD, professor of maternal and perinatal well being on the College of Birmingham, mentioned in a college information launch, “Ours is the primary examine to make use of the World Well being Group’s stringent strategies to point out that it’s doable for the virus to be unfold from the mom to child whereas within the womb, throughout childbirth, and after supply.
“Nonetheless, mother and father and healthcare professionals will be reassured that solely a really small proportion of infants born to moms with SARS-CoV-2 take a look at optimistic.”
An editorial on the examine in the identical journal highlights broadly various high quality of knowledge among the many research analyzed however echoes Thangaratinam: “General, findings from this evaluate appear reassuring.”
Mar 17 BMJ study and editorial
Mar 17 College of Birmingham news release