COVID-19 Scan for May 11, 2022

Combine-and-match mRNA COVID vaccines could supply extra Omicron safety

Researchers in Singapore found {that a} Moderna COVID booster following a two-dose Pfizer vaccine collection induced a stronger neutralizing antibody response in opposition to the Omicron variant in adults in contrast with an all-Pfizer collection, in line with a research in the present day in Scientific Infectious Illnesses.

The randomized managed trial included 100 wholesome adults who had accomplished their preliminary vaccination collection with Pfizer-BioNTech’s mRNA vaccine, 6 to 9 months previous to this research. Members had been assigned to get both a Pfizer booster or a Moderna booster in a couple of 1:1 ratio. The first finish level of the research was the extent of neutralizing antibodies in opposition to SARS-CoV-2 wild-type and variants of concern at day 28 post-booster.

Imply SARS-CoV-2 spike antibody titers had been decrease within the Pfizer-only group—22,382 worldwide items per milliliter (IU/mL; 95% confidence interval [CI], 18,210 to 27,517), in contrast with 29,751 IU/mL within the Moderna group (95% CI, 25,281 to 35,011; P = 0.034).

Extra considerably, the group with a Moderna booster had larger antibodies in opposition to variants of concern, together with Omicron. The median surrogate neutralizing antibody degree in opposition to Omicron within the all-Pfizer group was 72.8%, in contrast with 84.3% within the mixed-vaccine group.

Members ages 60 and older confirmed a extra sturdy immune response to mixing than youthful individuals, the authors mentioned; in that group, three Pfizer doses provided 64.6% safety in opposition to Omicron, in comparison with 89.2% for older adults who obtained a Moderna third dose.

“For the weak older age group particularly, a heterologous booster COVID-19 vaccine routine induces the next anti-spike antibody titer and a stronger neutralizing antibody response in opposition to the extremely infectious Omicron variant (~20% larger neutralization) than a homologous booster routine,” the authors concluded.
Could 11 Clin Infect Dis


Children’ odds of spreading COVID-19 in households rising with new variants

A scientific evaluate and meta-analysis printed in the present day within the Worldwide Journal of Infectious Illnesses means that whereas kids account for much less family COVID-19 transmission, their infectiousness seems to be on the rise as new SARS-CoV-2 variants emerge.

Researchers from the Nationwide Scientific Analysis Heart for Baby Well being and Problems in China led the research, which concerned looking out the PubMed and EMBASE databases from inception to Apr 20, 2022. Forty-eight research had been included for meta-analysis, and 47 had been chosen for case evaluation.

The pooled secondary assault fee (SAR) of pediatric index sufferers and family members was 0.20 (95% confidence interval [CI], 0.15 to 0.26) and 0.24 (95% CI, 0.18 to 0.30), respectively, within the meta-analysis. SAR refers back to the chance of transmission to a different individual.

Baby index instances had a 36% decrease COVID-19 transmissibility threat than adults, and youngster contacts had a 26% decrease threat (relative threat [RR], 0.64; 95% CI, 0.50 to 0.81 and RR, 0.74; 95% CI, 0.64 to 0.85, respectively). Youthful and older kids had been equally weak to an infection (RR, 0.89; 95% CI, 0.72 to 1.10).

Elevated family SAR was seen in kids all through completely different variant intervals (wild-type virus, 0.20; Alpha, 0.42; Delta, 0.35; and Omicron, 0.56). The estimated SAR of grownup family contacts was 0.32 (95% CI, 0.27 to 0.37) in 41 research.

Older adults had been considerably tied to the next SAR than youthful adults (RR, 1.45; 95% CI, 1.24 to 1.70 for adults youthful than 60; RR, 1.24; 95% CI, 1.02 to 1.50 for older adults).

Within the case evaluation, 10.3% of 78 household clusters had been related to an contaminated youngster, resulting in 7.7% of 207 secondary instances, versus 92.3% of these linked with an contaminated grownup. Pediatric infections had been implicated in 29.8% of 282 family contacts and 60.3% of 78 household clusters. Secondary infections unfold by kids made up 30% of 207 secondary infections, in contrast with 70% for adults.

“Given the possibly critical issues of pediatric COVID-19, vaccination analysis and implementation in kids stay a should,” the researchers concluded.
Could 10 Int J Infect Dis study

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