Fewer pregnant girls had extreme COVID-19 within the Omicron variant-era than in periods dominated by earlier strains, and vaccinated sufferers have been higher protected than their unvaccinated friends, in response to research printed yesterday within the American Journal of An infection Management.
Investigators from South Korea retrospectively examined the digital medical information of 224 pregnant girls who examined optimistic for COVID-19 and 82 quarantine deliveries from Nov 1, 2020, to Mar 7, 2022, at a single hospital. Common maternal age was 32 years.
Pregnant girls admitted to the hospital earlier than Jan 17, 2022 have been thought of to be contaminated with the Delta variant, whereas these after that date have been thought of contaminated with Omicron. Of the 224 girls, 39 (17%) have been vaccinated, and 185 (83%) have been unvaccinated towards COVID-19.
Most girls in each the Delta and Omicron intervals have been of their third semester (53.1% and 73.4%, respectively), however the authors stated the excessive percentages may very well be as a result of many have been admitted for supply.
The authors famous that the variety of pregnant girls contaminated with COVID-19 and having cesarean deliveries has risen steadily all through the pandemic in South Korea. The COVID-19 vaccination charge in pregnant girls in that nation is low, at 9.8%.
Relative affect of Omicron, vaccination unknown
Of the 224 girls, 42% examined optimistic for COVID-19 amid Omicron, and 4.1% of vaccinated girls and 25% of their unvaccinated counterparts on this interval had extreme sickness. A complete of two.6% and 16.2%, respectively, required supplemental oxygen.
Charges of reasonable or extreme maternal sickness fell from 30.0% amid Delta to 10.6% amid Omicron, as did charges of an infection (27.7% to 13.8%). The necessity for supplemental oxygen additionally dropped from 20.0% to five.3%.
Earlier than Omicron, 6.9% of the sufferers have been vaccinated towards COVID-19, rising to 31.9% after its emergence. Charges of reasonable or extreme sickness have been considerably decrease within the vaccinated group than within the unvaccinated group (25.4% vs 4.1%), as was the necessity for additional oxygen (16.2% vs 2.6%). Just one vaccinated affected person, who had bronchial asthma, wanted oxygen remedy.
“Total, sufferers had a extra favorable scientific course within the omicron period,” the authors wrote. “Furthermore, vaccinated sufferers have been higher protected than non-vaccinated sufferers, indicating the significance of vaccination towards COVID-19.”
However the researchers acknowledged that they could not decide whether or not the lowered COVID-19 severity in vaccinated pregnant girls was attributable to the vaccination, or was as a consequence of traits of Omicron. “Additional research are required to determine whether or not the outcomes improved as a result of decreased severity of the illness attributable to the omicron variant or the protecting results of vaccination,” they concluded.