More (mostly mild) side effects when flu vaccine given with COVID booster

Self-reported information from almost 1 million People present an 8% to 11% increased fee of principally delicate systemic hostile occasions after simultaneous seasonal flu vaccine and mRNA COVID-19 booster (third) doses than with the COVID-19 booster alone.

Within the study, printed right now in JAMA Community Open, the Facilities for Illness Management and Prevention (CDC) COVID-19 Response Group and Emory College analyzed charges of systemic hostile occasions amongst 981,099 People aged 12 years and older within the week after both simultaneous flu and COVID-19 booster doses or the booster alone from Sep 22, 2021, to Might 1, 2022. Volunteers responded to not less than one well being survey by means of the CDC’s smartphone-based v-safe monitoring system throughout the research interval.

The authors famous that present medical CDC guidance states that COVID-19 vaccines could also be given with out regard to timing of different vaccines, together with throughout the identical vaccination go to. Authorization of COVID-19 vaccine boosters in the USA coincided with the beneficial interval for flu vaccination, rising the percentages of simultaneous receipt.

Fatigue, headache, muscle aches most reported

Of the 981,099 volunteers, 92,023 (9.4%) reported having obtained simultaneous flu and COVID-19 booster vaccination. Of those individuals, 59.7% have been feminine, 40.6% have been aged 12 to 49 years, 25.8% have been 50 to 64, 27.0% have been 65 to 74, and 6.6% have been 75 or older.

A complete of 58.9% of 61,390 individuals who concurrently obtained the flu vaccine and the Pfizer/BioNTech COVID-19 booster and 68.6% of 30,633 of those that concurrently obtained the flu vaccine and the Moderna booster reported systemic hostile reactions.

Members who concurrently obtained the flu and Pfizer vaccine (aOR, 1.08; 95% CI, 1.06 to 1.10) or the flu and Moderna vaccine (aOR, 1.11; 95% CI, 1.08 to 1.14) have been barely extra more likely to report a systemic response than those that obtained a COVID-19 booster alone.

Most reactions have been delicate or average and have been reported the day after vaccination. The most typical systemic reactions have been fatigue, headache, and muscle aches.

Lower than 1% sought hospital care

A complete of 19.0% of respondents receiving simultaneous flu and COVID-19 booster vaccination with Pfizer and 26.8% of flu and Moderna recipients reported well being results. Amongst Pfizer recipients, 15.5% mentioned they could not carry out routine every day actions, as did 22.2% of Moderna recipients. However lower than 1% wanted hospital care.

Hospital admission information have been obtainable for 19 of twenty-two individuals; of them, 10 mentioned their hospitalization was unrelated to vaccination or was reported in error. The remaining sufferers indicated they have been admitted for therapy of extreme vomiting, supraventricular tachycardia, irregular coronary heart rhythms, chest ache, an autoinflammatory illness exacerbation, kidney an infection, low oxygen ranges, or stroke.

Recipients of simultaneous flu and Pfizer boosters weren’t extra possible than recipients of a booster alone to report a “well being impression” inside per week of vaccination (aOR, 0.99; 95% CI, 0.97 to 1.02), whereas flu and Moderna vaccine recipients have been barely extra more likely to report a well being impression throughout the first week (aOR, 1.05; 95% CI, 1.02 to 1.08) than recipients of a Moderna booster alone.

The researchers mentioned that whereas simultaneous administration of each vaccines is environment friendly and should improve uptake of the vaccines, it’s related to the next danger of systemic hostile occasions.

However in a associated commentary, Kathryn Corridor, PhD, MPH, of Brigham and Ladies’s Hospital; Valerie Stone, MD, MPH, of the Boston Public Well being Fee; and Bisola Ojikuto, MD, MPH, of Massachusetts Common Hospital, mentioned that concomitant administration of the flu vaccine and COVID-19 booster may improve the flu vaccination fee, which was solely 50.2% throughout the 2020 to 2021 season.

“Though logistical challenges might function limitations to the implementation of twin vaccination, organizing for provision of each influenza vaccination and COVID vaccination inside medical settings and at community-based nonclinical venues can be advantageous and should improve the probability of uptake,” they wrote.

“Given the small improve in fee of hostile occasions reported by Hause et al, well being care programs must be inspired to develop routine and streamlined processes for coadministration of those vaccinations.”

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