Omicron BA.2 tied to more symptoms and, rarely, brain swelling in kids

UK study means that Omicron BA.2 is tied to extra signs and larger disruption in day by day actions than BA.1, and Taiwanese researchers describe deadly cerebral edema in six kids hospitalized for BA.2.

Imperial School London researchers tracked SARS-CoV-2 transmission and signs amongst 1,542,510 randomly chosen English adults, together with 17,448 COVID-19 sufferers, from Might 1, 2020, to Mar 31, 2022.

A larger proportion of BA.2 sufferers (75.9%) reported no less than certainly one of 26 signs, in contrast with 70.0% of these with BA.1, 63.8% with Delta, 54.7% with Alpha, and 45.0% with the wild-type virus.

Sufferers with wild-type, Alpha, or Delta infections had been at highest danger for lack of sense of odor (odds ratios [ORs], 49.7, 37.8, and 73.4, respectively) and style (ORs, 35.9, 38.9, and 68.1, respectively), whereas these with BA.1 or BA.2 had larger odds of flu- and cold-like signs.

A complete of 17.6% of BA.2-infected folks mentioned their signs had affected their potential to finish day by day actions “so much,” in contrast with 10.7% with BA.1 and 10.5% with Delta infections.

“With restrictions lifted and routine testing restricted in lots of international locations, monitoring the altering symptom profiles related to SARS-CoV-2 an infection and results on day by day actions will develop into more and more essential,” the authors wrote.

In Taiwan, researchers examined medical information from six BA.2-infected kids recognized as having acute fulminant cerebral edema (normally deadly, rapid-onset mind swelling) from Apr 13 to Jun 30, 2022.

All six initially had shock and considerably elevated inflammatory biomarkers, with 5 quickly progressing to multi-organ failure and diffuse blood-vessel clotting and three creating acute respiratory misery.

The researchers mentioned that fever above 41oC (105.8oF) and atypical advanced fever-related seizures are early indicators of cerebral edema in pediatric sufferers. “The speedy and fulminant course highlights a necessity for shut monitoring of cardiopulmonary and hematological capabilities in such sufferers, particularly throughout the first day after the onset of neurological indicators,” they wrote.

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